Fig. 8
From: Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1
The expression patterns of representative splicing events regulated by SRSF1 in vivo and the clinical significance of splicing switching of PTPMT1. a Splicing pattern of PTPMT1/SMARCD1/GAB1/TERF1 in breast cancer and their paired adjacent tissues (n = 6) as detected by RT-PCR. b Comparison of the PSI of PTPMT1/TERF1/SMARCD1 in the 113 cancer and matched normal tissues from TCGA dataset. c Kaplan-Meier analysis of the OS of the high- (low PSI of PTPMT1 and high expression of SRSF1) and low-risk (high PSI of PTPMT1 and low expression of SRSF1) group in stage I-II or stage III-IV cohort based on TCGA data. The median of PSI of PTPMT1 or mRNA expression of SRSF1 are used as the cutoff. d The model of how SRSF1 mediates BRCA progression through modulating AS