Fig. 4

Exosomal miR-31-5p directly targeted SATB2. a-b Luciferase activities of WT or mut 3’UTR in A549 cells after transfection of miR-31-5p mimic or HExo. c Expression of SATB2 after transfection miR-31-5p mimic under hypoxic or normoxic conditions. d Expression of SATB2 after treatment of HExo. Scratch assays (e) and Transwell invasion assays (f) results after transfection of si-SATB2 and/or miR-31-5p inhibitor in A549 cell line. Data are represented as the mean ± SD from three independent experiments (*, P<0.05; **, P<0.01; ***, P<0.001)