Fig. 5

Exosomal miR-31-5p promoted metastasis of LUAD cells in vivo. a Representative images of lung metastasis in nude mice after tail intravenous injection of A549 cells treated with HExo or miR-31-5p inhibitor (31-inhibitor) or treated with HExo and miR-31-5p inhibitor (HExo + 31-inhibitor). Scale bar, Morphology 500 mm; HE 50 μm. b Numbers of metastatic lung nodules in each group. c Overall survival times of each group after tail intravenous injection of A549 cells. d Representative pictures of E-cadherin, Vimentin and SATB2 expression in lung metastatic nodule by immunohistochemistry staining. Scale bar, 50 μm