Fig. 1

TRIM37 is overexpressed and associated with poor outcome of RCC. A, The heat map of microarray chip in RCC tumors showed that TRIM37 was upregulated in tumor specimens than normal tissues (Foldchange> 1.5, P < 0.05 was regarded as significant). B, GEO datasets and NMU_RCC cohort1 validated abnormal TRIM37 expression in tumors than normal tissues. C, TRIM37 protein levels was elevated in tumorous samples than normal ones of RCC patients. D, TCGA datasets showed 5% alteration of TRIM37 in RCC patients, 69% of which were mRNA high. E, RCC tumors with gain or amplification of TRIM37 had significantly higher transcription levels than shadow deletion or diploid alterations in TCGA cohort. F, IHC staining showed TRI37 intensity was higher than those in normal kidney tissues. G, Kaplan-Meier survival analysis declared TRIM37-high patients had poorer cumulative overall and relapse-free survival in NMU_RCC cohort 2. High TRIM37 also predicted shorter overall survival time in TCGA RCC patients