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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype

Fig. 5

RANBP3L is downregulated in RCC cohorts and has a KIRC specific prognostic value. A Mean log2 expression of RANBP3L in all TCGA RCC samples compared to normal tissue. Values were analyzed with a student’s-T test and are presented in a whiskers 1–99 percentile plot, ***, p<0.001. n = the number of available samples in the indicating TCGA cohort. B Kaplan Maier Plot of RANBP3L for RCC (all cohorts). C Among RCC subtypes RANBP3L expression is downregulated in KIRC, KICH and KIRP. Values were analyzed with a student’s-T test and are represented in a whiskers 1–99 percentile plot, ***, p<0.001. n = the number of available samples obtained from TCGA [32]. D-F Kaplan Maier Plot for RANBP3L in the different RCC subtypes KIRC (D). KICH (E) KIRP (F). All Kaplan Maier Plots were generated using GEPIA2 tool [33] with the corresponding RCC cohort of TCGA data and solid tissue normal samples (N) (high): Samples with expression level higher than the median are considered as the high-expression cohort. N (low): Samples with expression level lower than the median are considered the low-expression cohort. Logrank test

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