Table 1 Top 30 up and downregulated genes in RANBP3L-deficient cells. Genes deregulated under isosmotic and hyperosmotic cell culture conditions are highlighted in bold
Top 30 upregulated genes | Top 30 downregulated genes | ||||||
|---|---|---|---|---|---|---|---|
300 mosmol/kg | 600 mosmol/kg | 300 mosmol/kg | 600 mosmol/kg | ||||
Gene | log2fold change | Gene | log2fold change | Gene | log2fold change | Gene | log2fold change |
Pmp22 | 8.10 | Unc5b | 8.88 | Hoxa9 | −10.23 | Zfp422 | −9.10 |
Unc5b | 7.56 | Pmp22 | 7.65 | Hoxa10 | −9.91 | Plagl1 | −8.81 |
Tmem30b | 7.35 | Syt17 | 7.532 | Epdr1 | −9.39 | Sh3gl2 | −8.71 |
Syt17 | 6.84 | Tmem30b | 7.41 | Hdgfrp3 | −9.31 | Hoxa10 | −8.59 |
BC025446 | 6.19 | Ica1 | 6.63 | Zfp422 | −9.28 | Asb4 | −8.44 |
Sparc | 6.08 | BC025446 | 6.55 | Atp6v0e2 | −8.80 | Atp6v0e2 | −8.44 |
Gnao1 | 5.85 | Siglecg | 6.47 | Sh3gl2 | −8.77 | Galnt11 | −8.38 |
Ica1 | 5.84 | Gnao1 | 5.86 | Phactr2 | −8.64 | Arrb1 | −8.31 |
Lrrc32 | 5.66 | Sparc | 5.08 | Eif5a2 | −8.33 | Hoxa9 | −8.14 |
Gcnt3 | 5.55 | Gcnt3 | 5.08 | Galnt11 | −7.95 | Smoc1 | −8.13 |
Acp5 | 5.51 | Parvb | 4.96 | Inmt | −7.84 | Phactr2 | −7.98 |
Col4a1 | 5.35 | Parm1 | 4.91 | Smoc1 | −7.73 | Inmt | −7.86 |
Gstk1 | 5.32 | Cntfr | 4.85 | Rnf217 | −7.72 | Epdr1 | −7.80 |
Col4a2 | 5.20 | Cbr1 | 4.84 | Hebp2 | −7.66 | Aldh2 | −7.57 |
Col4a3 | 5.15 | Acp5 | 4.82 | Aldh2 | −7.49 | Hdgfrp3 | −7.57 |
Parm1 | 5.03 | Col4a3 | 4.80 | Ccdc91 | −7.48 | Ccdc91 | −7.39 |
Siglecg | 4.89 | Parvg | 4.77 | Hoxd9 | −7.46 | Hebp2 | −7.36 |
Itgb7 | 4.71 | Sytl5 | 4.70 | Hoxd8 | −7.29 | Neil3 | −7.20 |
Gc | 4.64 | Mcpt8 | 4.63 | Slc9a7 | −7.26 | Slc9a7 | −7.14 |
Parvb | 4.63 | Gstk1 | 4.34 | Sim1 | −7.25 | Adgra1 | −7.08 |
Dmkn | 4.62 | Sftpd | 4.24 | Sipa1l2 | −7.15 | Sim1 | −7.04 |
Cbr1 | 4.59 | Myo7b | 4.22 | Bckdhb | −7.05 | Zfhx4 | −7.03 |
Myo7b | 4.55 | Serpinb9b | 4.16 | Tspan13 | −7.02 | Nrk | −7.00 |
Lrrc61 | 4.42 | Dhrs9 | 4.16 | Enox2 | −6.96 | Enox2 | −6.99 |
Col4a4 | 4.36 | Nid1 | 4.14 | Asb4 | −6.95 | Kitl | −6.90 |
Bgn | 4.34 | Col4a2 | 4.13 | Hoxd10 | −6.73 | Hoxd9 | −6.85 |
Trex2 | 4.28 | Ociad2 | 4.11 | Prdm5 | −6.68 | Tspan13 | −6.77 |
Inhba | 4.18 | C130073F10Rik | 4.07 | Pdlim1 | −6.68 | Eif5a2 | −6.75 |
H60c | 4.13 | Col4a1 | 4.05 | Nrk | −6.66 | Hoxa7 | −6.64 |
Glipr2 | 4.12 | Lypd5 | 4.03 | Hoxa7 | −6.62 | Sipa1l2 | −6.61 |