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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN

Fig. 4

RPPA-based signaling network analyses of tumor/normal Early/Late PDCOs. A, B Unsupervised hierarchical clustering analyses illustrating changes in expression and/or activation of the analytes measured by RPPA across all samples (A) and in P12 PDCOs derived from normal and matched tumor cells (B). C, D Target analyses of the PI3K/AKT/mTOR and the MAPK signaling pathway of Early/Late tumor-derived PDCOs for patients P12 and P14 are shown, respectively. Proteins with missing values were not included in the unsupervised analyses

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