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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer

Fig. 6

The HOMER3 membrane phenotype associates with bladder cancer aggressiveness and worst prognosis. A) HOMER3 is not expressed by the healthy urothelium but could be found at different bladder cancer stages (Ta-T4) and in metastases, with significant accumulation at the cell membrane for high-grade NMIBC and MIBC bladder cancer. HOMER3 was scored based on the number of positive cases and sub-cellular location (cytoplasm vs membrane and cytoplasm). HOMER3 was not expressed in healthy urothelium. On the other hand, the number of positive cases showing membrane staining increased with the severity of the lesions, being also present in most metastases. A significant association between HOMER3 at the cell membrane and high-grade tumours of stages T1 and higher could be observed (Ta vs ≥ T1: 5.3% vs 28.4%; p = 0.038; Chi-square). B) The overall survival of bladder cancer patients exhibiting HOMER3 at the plasma membrane (memHOMER3) was reduced compared to patients not showing this molecular feature. The survival curve in the upper panel highlights the association between the memHOMER3 and decreased OS (83 vs 148 months; log-rank p = 0.035). The lower panel shows that this is also true for the MIBC subgroup (15 vs 64 months; log-rank p = 0.001)

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