RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA

Table 2 Correlation between IMP3, MEKK1, MEK1, p-ERK expression and clinicopathologic features in 282 cases of CRC tissues.

Parameters	n	IMP3			MEKK1			MEK1			p-ERK
Parameters	n	-	+	P value	-	+	P value	-	+	P value	-	+	P value
Age(years)
<57	133	60	73	0.411	35	98	0.470	34	99	0.785	58	75	0.908
≥57	149	60	89		45	104		36	113		66	83
Gender
Male	165	66	99	0.303	50	115	0.392	37	128	0.268	71	94	0.705
Female	117	54	63		30	87		33	84		53	64
AJCC stage
I+II	102	54	48	0.008*	37	65	0.027*	28	74	0.442	54	48	0.022*
III+IV	180	66	114		43	137		42	138		70	110
T stage
T1+T2	47	27	20	0.024*	17	30	0.194	12	35	0.902	25	22	0.163
T3+T4	235	93	142		63	172		58	177		99	136
N stage
N0	117	60	57	0.013*	41	76	0.036*	33	84	0.268	58	59	0.111
N1+N2	165	60	105		39	126		37	128		66	99
M stage
Yes	46	14	32	0.069	12	34	0.707	10	36	0.597	17	29	0.295
No	236	106	130		68	168		60	176		107	129
Differentiation
Poor	69	33	36	0.308	21	48	0.661	17	52	0.967	31	38	0.854
Well and moderate	213	87	126		59	154		53	160		93	120

ISSN: 1756-9966