Fig. 7

Combination of TPL and erastin potently inhibits tumorigenicity of HK1 cell in vivo. a Growth curve of xenograft tumors in mice treated with single reagent or combination of TPL (0.1 mg/kg QD) with erastin (10 mg/kg QD) (n = 5/group). b Xenograft tumors in live mice were visualized in vivo bioluminescence imaging system. c The macroscopic view of mice and xenograft tumors at the endpoint of experiment. d The average tumor weight from different groups. Values are shown as mean ± SD (n = 5). e H&E staining of xenograft tissue sections. *P < 0.05, **P < 0.01, ***P < 0.001. Scale bar, 50 μm