Fig. 2

Molecular targets of LncRNAs responsible for T regulatory cells differentiation and inhibition of proliferation. In Treg cells, Lnc-EGFR stimulates FOXp3 causing inhibition of IFN. While Lnc-SNHG1 and Lnc-SOX5/SOX3 stimulates IDO production. Lnc-SNHG20, Lnc-MALAT1, Lnc-CECR7 and LINC00473 accelerates PD-1 and PD-L1. While Lnc-NKX2-1-AS1 and Lnc-Rp11-51IM6.8 inhibit PD-1 and PD-L1