Fig. 3

LncRNA mediated molecular pathways in B cell maturation. In bone marrow, the development of pro/pre/immature B cells are mediated by Lnc-CRNDE, SMAD1-AS1, MYB-AS1 and LEF1-AS1. lncRNA BIC plays a major role in hemotopoises peripheral compartments Naïve B cells and FAS activations are mediated by LncRNAs BIC and FAS-AS1. The BCR signalling is mediated by Lnc-GVINP1. Linc-BM742401, Oct-4 mediated MIAT and MALAT1 cause CLL proliferation, Tumoral B cell formation and multiple myeloma, respectively