Fig. 8

Effects of CD151 on NSCLC cell growth in vivo. a Slower growth and smaller volume of tumors were observed in nude mice subcutaneously injected with CD151-silenced A549 cells when compared with that in nude mice injected with control A549 cells (n = 4). b&f Each tumor collected from indicated mice was weighed. c&g CD151 mRNA expression in tumors was detected by qRT-PCR analysis. d&i Tumor lysates were analyzed by western blot. CD151 and EGF signaling pathways was evaluated in western blot with indicated antibodies. eCD151 overexpression in xenograft nude mice (n = 4) at the experimental endpoint; tumors were dissected and photographed as shown. h Immunohistochemical staining for CD151 was quantified based on staining intensity. *P < 0.05; **P < 0.01, ***P < 0.001