Fig. 9

The impact of EGFR or FAK inhibition on tyrosine phosphorylation cascade. a-c The impact of EGFR or FAK inhibition on EGF-mediated tumor cell motility in CD151-overexpressed A549 and H1299 cells. Inhibition of EGFR or FAK was carried out by using Gefitinib or Lapatinib or TAE226 at 10 µM or 20 µM or 4 µM. d Schematic illustration of functional roles of CD151-α3β1 integrin complexes in NSCLC