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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway

Fig. 5

ZIP13 promotes ovarian cancer cell migration, invasion and adhesion in vitro. a, b. The transwell invasion and migration assays were conducted using the 24-well transwell chambers. The migratory or invasive cells were visualized and counted in at least three random fields under a microscope. c, d. A vertical wound was made through confluent monolayer cells. Then the wound areas were photographed and quantified after 48 h. e, f. Calcein-AM-labeled cells were seeded into 96-well plates pre-coated with either Matrigel or fibronectin (FN), and allowed to adhere at 37 °C for 30 min. The fluorescent signal of the adherent cells was imaged under the microscope and quantified with a fluorescent plate reader. Results indicated were mean values of three independently repeated experiment. *P < 0.05

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