Fig. 2
From: Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation
Bcl-X pre-mRNA splicing and structures of splicing isoforms. a. Alternative splicing mode and splicing regulation. Splicing occurred closer to the 5'PSS of exon 2 produces the long isoform Bcl-xL. Alternative splicing occurred near the 5' DSS of exon 2 produces the short isoform Bcl-xS. In addition, distinct cis-elements and splice factors bind to cis-elements to influence the alternative 5' splice site selection of Bcl-x pre-mRNA. b. General characteristics of isoforms spliced from Bcl-x pre-mRNA. c. The protein structures of Bcl-xL. The secondary structure of Bcl-xL and the position in the space of BH domains (up). Tertiary structure of Bcl-xL and the BH domain and hydrophobic groove are showed (down)