Table 3 Splice switching oligonucleotids used to modulate Bcl-x pre-mRNA splicing
From: Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation
Cells types | Sequence | Length | Chemistry | Ref |
|---|---|---|---|---|
K562 | 5'-GCTTGGTTCTTACCCAGCCGCCGTT-3' | 25 mer | vMO | [5] |
Primary HSCs | 5'-TGGTTCTTACCCAGCCGCCG-3' | 20 mer | 2'-OMe-PS | [97] |
U87, U251 | 5'-TGGTTCTTACCCAGCCGCCG-3' | 20 mer | 2'-MOE-PS | [142] |
B16F10 | 5'-TGGTTCTTACCCAGCCGCCG-3' | 20 mer | 2'-MOE-PS | [143] |
Human RPE | 5'-TGGTTCTTACCCAGCCGCCG-3' | 20 mer | 2'-MOE | [144] |
A549 | 5'-CTGGATCCAAGGCTCTAGGT-3' | 20 mer | 2'-MOE | [145] |
PC-3 | 5'-ACCCAGCCGCCGUUCUCC-3' | 18 mer | 2'-OMe-PS | [146] |
MCF-7 | 5'-ACCCAGCCGCCGUUCUCC-3' | 18 mer | 2'-OMe-PS | [146] |
Hela | 5'-ACCCAGCCGCCGUUCUCC-3' | 18 mer | 2'-OMe-PS | [146] |