Fig. 1

Regulation of reversible ADP-ribosylation. ADP-ribosylation is a post-translational modification of the protein, the use of NAD+ as a donor, PARPs act as synthases to ligate ADP-ribose to target proteins, ADP-ribose is also a reversible process, ADP-ribose can be removed by hydrolytic enzymes, such as PARG, ARH3 and so on