Fig. 7
From: HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML
HCK deletion has almost no effect on normal haematopoiesis. (a-b) Average frequencies and numbers of differentiated cells in HCK−/− and HCK+/+ mice. (c-d) Average stem cell frequencies and absolute numbers of stem and progenitor cells in HCK−/− and HCK+/+ mice. (e) Experimental scheme for investigating normal haematopoietic reconstruction. (f) No defect was found in the homing of HCK−/− BM cells to the BM. (g) Chimaerism assessment in peripheral blood (n = 10). (h-i) Average frequencies and numbers of differentiated cells in the reconstruction of the haematopoietic cell system in HCK−/− and HCK+/+ mice. (j-k) Average stem cell and progenitor cell frequencies and absolute numbers of stem cells and progenitor cells in the reconstruction of the haematopoietic cell system in HCK−/− and HCK+/+ mice. (l) Frequency of LSK cells in bone marrow on the indicated days after 5-Fu injection. (m) Average stem cell and progenitor cell frequencies in in HCK−/− and HCK+/+ mice at day 28 after 5-Fu injection