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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation

Fig. 6

In the POSTNHigh PDX liver cancer model, targeting POSTN/αVβ3 pathway can effectively inhibit tumor growth. a Experimental diagram; b POSTN immunohistochemical staining (Left panel) and WB (Right panel) confirmed the successful construction of POSTN High and POSTN Low PDX tumor models; c In POSTNHigh PDX model, the inhibitory effects of cilengitide and lenvatinib on the growth of liver cancer were detected; FMV represents Final Medium Volume; n = 12, *P < 0.05, ***P < 0.001; d In POSTNLow PDX model, the inhibitory effects of cilengitide and lenvatinib on the growth of liver cancer were detected; FMV represents Final Medium Volume; n = 12, **P < 0.01, ns means no significant; e The expression of Ki-67, CD31 and CD133 were detected by immunohistochemistry. The number of Ki-67 positive cells and microvascular density (MVD) were detected by quantitative analysis on the right bar graph, Data represent mean + SEM of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001

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