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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target

Fig. 3

The strategy of targeting NETs or blocking NETs-mediated effect. a The induction of cancer-associated NETs formation is mediated by the interaction of cancer or stroma –derived chemokines/cytokines and the specific receptor present on neutrophils. Blockade of the chemokines/cytokines or the receptors on neutrophils can inhibit the induction of NETs formation. b Inhibition of NETs formation via targeting key players such as NOX2, NE, MPO or PAD4 in the formation pathway. c Direct destruction of NETs structure via DNase. d NETs-mediated pro-tumor effect is through the interaction of NETs and cancer cells. Block their interaction via targeting the mediators can prevent NETs effect on cancer cells

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