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Table 2 Mechanisms of NETs Formation in the Context of Cancer

From: Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target

Mouse model

Detected NETs marker

NETs Formation Mechanism

Reference

Lewis lung carcinoma; Breast carcinoma; CML

WB/IF: H3Cit; IF: DNA

Plasma DNA Count;

FACS: H3Cit+ Neutrophils

Cancer cell-derived G-CSF

[41]

Melonoma; Lewis lung carcinoma

WB/IF: H3Cit; IF: DNA

Cancer cell-derived G-CSF

[42]

Colorectal cancer liver metastasis

IF: MPO+ /H3Cit+/extracellular DNA+

Tumor-derived IL-8

[43]

Gall bladder cancer

IF: NE+ /H3Cit+/extracellular DNA+

Cancer cell-derived IL-8

[44]

Lewis lung carcinoma; Breast carcinoma;

Colon carcinoma

IF: H3Cit+/extracellular DNA+

Cancer cell-derived CXCR1 and CXCR2 ligands

[45]

Lung metastasis of breast cancer

IF: MPO+ /H3Cit+/extracellular DNA+

Cancer cell-derived Cathepsin C

[46]

melanoma

Pancreatic adenocarcinoma

Lung adenocarcinoma

IF: MPO+ /H3Cit+/extracellular DNA+

Stroma-derived Amyloid β

[47]

  1. WB Western Blot, IF Immunofluorescence, H3Cit citrullinated histone H3, MPO myeloperoxidase, NE neutrophil elastase, CXCR CXC Chemokine Receptor