Fig. 8

Correlated expression of DLEU2 and its downstream signaling molecules in EC. a Genomic profiling of DLEU2 and its downstream signaling molecules in human TCGA EC tissues determined by cBioPortal analysis. b qRT-PCR analysis of the indicated genes and miRNAs in EC and adjacent normal tissues. c Correlation of DLEU2 levels with the expression of its downstream signaling molecules in EC tissues as assessed using qRT-PCR analysis. d A scheme depicting how DLEU2 induces EMT and sustains glycolysis in EC via activating the HK2 signaling by competitively binding with miR-455 and by modulating the EZH2/miR-181a pathway. *P < 0.05