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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer

Fig. 5

mC4BPA stimulation in mPBMCs and murine PDAC cells. a The mC4BPA peptide is composed of 30 amino acids from the C-terminus of mC4BPA. b mPBMC culture protocol. c Representative scatter plots of mCD4+ and mCD8+ T cells in the control and mC4BPA peptide stimulation groups, analyzed using flow cytometry. d Number of mCD4+ and mCD8+ cells on each group. After mPBMCs were stimulated with mC4BPA peptide, the numbers of both mCD4+ and mCD8+ T cells were significantly increased compared with those in the control group (*P < 0.05, Welch’s t-test). e mC4BPA peptide stimulation increased cell proliferation in PKCY cells compared with that in control cells (*P < 0.05, Welch’s t-test). Results are represented as the mean ± SD. Each experiment was performed at least three times.

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