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Table 2: Univariate and multivariate analyses for 5-year survival of patients

From: C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer

 

n=171

Univariate analysis

Multivariate analysis

Hazard ratio (95%CI)

P value

Hazard ratio (95%CI)

P value

Age (year) (66/67)

(83/88)

1.54 (0.79-3.02)

0.19

  

Gender (male/female)

(99/72)

1.17 (0.60-2.28)

0.63

  

Histological grade (G3,4/G1,2)

(18/153)

0.78 (0. 27-2.15)

0.78

  

Tumor volume (6335/6335<)

(82/89)

1.05 (0.54-2.05)

0.86

  

pT3,4/pT1,2

(167/4)

2.55 (0.34-18.65)

0.36

  

pN (+/−)

(128/43)

2.96 (1.43-6.14)

0.0036*

3.01 (1.37-6.59)

0.006*

R1,2/R0

(70/101)

2.12 (1.03-4.33)

0.034*

1.66 (0.78-3.54)

0.19

Neoadjuvant therapy (+/−)

(74/97)

1.02 (0.52-2.00)

0.944

  

Adjuvant chemotherapy (+/−)

(146/25)

0.42 (0.13-1.31)

0.11

  

Stromal C4BPA (Low/High)

(75/96)

2.50 (1.22-5.10)

0.0096*

2.54 (1.18-5.48)

0.017*

Stromal CD40 (Low/High)

(82/89)

1.05 (0.54-2.05)

0.86

  

CD8 expression (Low/High)

(77/94)

2.06 (1.02-4.13)

0.037*

1.67 (0.80-3.50)

0.16

  1. Cox’s proportional hazard model
  2. p Pathological findings, T Primary tumor, N Regional lymph nodes, R Surgical curability, CI Confidence interval, *: significant value