Fig. 3
From: Cancer: a mirrored room between tumor bulk and tumor microenvironment
Formation of a pre-metastatic niche. The formation of a pre-metastatic niche (with both CAFs and TAMs) occurs before metastatic growth and it is promoted by primary tumor-derived soluble factors and exosomes. The specific integrins patterns on the exosome surface may condition the specific cellular targets of such exosomes. Therefore, the molecular signature of the pre-metastatic niche and its site-selective location may be considered as a reflection of the primary tumor molecular signature. Created with BioRender.com