Fig. 3

Differentially expressed proteins are primarily differentially expressed genes, but not vice versa, in KRAS mutants compared to BRAF V600E cells. Differentially expressed proteins (DEPs) were intersected with   differentially expressed genes from RNA sequencing data, comparing isogenic RKO BRAF V600E cells with KRAS G12C (a), G12D (b), G12V (c) and G13D (d). Differential expression was defined as ½log2 FC½ > 1 and adjusted P < 0.05 (hypergeometric distribution). Intersecting DEGs and DEPs are listed with genes common to all four comparisons in bold.