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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

Fig. 8

Effects of HIF1α and HIF2α expression on ccRCC patient survival probability: Kaplan-Meier survival analyses of patient OS from the TCGA-ccRCC cohorts of ccRCC for HIF1α (A) or for HIF2α (B) were presented. A ccRCC patients were grouped into the high HIF1α expression group versus the low HIF1α expression group based on the median HIF1α mRNA expression. B ccRCC patients were grouped into the high HIF2α expression group versus the low HIF2α expression group based on the median HIF2α mRNA expression. Each p-value for its significance from the high expression versus low expression of HIF1α (A) or HIF2α (B) was calculated using the log-rank test. The figures were performed using R version 4.0.3

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