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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway

Fig. 7

MiR-599 overexpression altered CRC cell growth, motility and angiogenesis by binding to ONECUT2. (A) The protein level of ONECUT2 in SW620 and DLD-1 cells transfected with ONECUT2 or vector was measured via western blot assay. (B-H) SW620 and DLD-1 cells were transfected with miR-NC + vector, miR-599 + vector or miR-599 + ONECUT2. (B-F) The proliferation, colony formation, migration, invasion and angiogenesis of SW620 and DLD-1 cells were investigated by EdU assay, colony formation assay, wound healing assay, transwell assay and tube formation assay, respectively. (G and H) The protein levels of ZEB2, E-cadherin, Vimentin and VEGFA in SW620 and DLD-1 cells were measured via western blot assay. *P < 0.05, **P < 0.01, ***P < 0.001

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