Fig. 2

GSCs and GdECs show extraordinary resistance to targeted inhibition. A Kinase inhibitor library screening in a representative GSC line either in stem cell medium (GSC) or in endothelial conditions (GdEC) and in HMVECs. Cell viability is reported as mean ± SD (n = 3) of standardized values (z score) for each cell line treated with the kinase inhibitor library at 1 μM for 72 h. B Concentration-response assays on all the four selected GSC lines either in stem cell medium (GSC) or in endothelial conditions (GdEC), for the set of chemotherapeutics yielded a significant decrease in cell number. Cell viability is reported as mean ± SD (n = 3) for each cell line and drug tested for 72 h