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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survival

Fig. 5

Functional categories of immune-related genes and patient survival. (A) Four functional categories of immune-related genes. (B) Cancer cell-intrinsic expression of genes associated with immune checkpoint activation/inhibition or HLA class I molecules had no prognostic impact. (C) Significant association between cancer-intrinsic expression of HLA class II molecules (DRB1, DQB1, DRA, DRB5, and DPA1) and patient survival. (D) Patient’s survival based on 4-quantiles of the HLA-II signatures from CCOs. Patients with no/very low HLA-II signature in CCOs showed unfavorable prognosis, while the other groups showed similarly favorable prognoses. (E) Correlation between mRNA expression of HLA class II genes in CCOs and protein expression by IHC in primary tissues (Wilcoxon rank-sum test). No prognostic relevance of the HLA-II signature measured from primary cancer tissues was observed in this dataset (F) and in the public TCGA dataset (G). CCO, colorectal cancer organoid; IHC, immunohistochemistry

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