Fig. 7From: Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survivalCharacteristics of TIM of primary tissue. (A) Classification of the TIM in 87 colorectal cancer samples. (B) No association between TIM status and Ca-IIP group (Fisher exact test). The TIM status was associated with intrinsic HLA-I expression (C) but not intrinsic HLA-II expression (D) in CCOs (Wilcoxon-rank sum test). (E) Patient survival based on TIM status (log-rank test). (F) High CD8+ T cell exhaustion score in MSI-H/hypermutated tumors (Wilcoxon-rank sum test). TIM, tumor immune microenvironment; CCO, colorectal cancer organoid; Ca-IIP, Cancer cells with intrinsic immunogenic properties; MSI-H, microsatellite instability highBack to article page