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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Statins: a repurposed drug to fight cancer

Fig. 4

The relationship between statins and ferroptosis. Iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation are prerequisites for the activation of cell death by ferroptosis. Ferroptosis is governed by three antioxidant axes, i.e., the GSH/GPX4, FSP1/CoQ10/NAD(P)H and GCH1/BH4 axes. The FSP1/CoQ10/NAD(P)H axis relies on the mevalonate pathway to generate CoQ10. IPP, the precursor of CoQ10, is also a limiting substrate for enzymatic isopentenylation of Sec-tRNA, thereby influencing the expression of GPX4. Statins regulate the GSH/GPX4 and FSP1/CoQ10/NAD(P)H axes via the mevalonate pathway, thereby inducing cell death by ferroptosis

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