Fig. 3
From: Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
HSPD1 knockdown induces a metabolic impairment and reduces tumor growth in vivo. Quantification of basal respiration, indicative glycolysis and ATP-linked respiration of H1299 (A) and A549 (B) shHSPD1 cells compared to pLKO cells. Bars are average values of biological replicates ± SD. P-values are from unpaired t-test. * < 0.05, **** < 0.0001. Images of tumors from NSG mice injected subcutaneously with H1299 (C) or A549 (F) pLKO or shHSPD1 cells. Graph showing tumor volume of H1299 (D) or A549 (G) shHSPD1 cells compared to pLKO cells. P-values are from two-way ANOVA. Points are average of tumors in (C, F) ± SD. **** < 0.0001. Bar graph showing weight of H1299 (E) and A549 (H) shHSPD1 tumors compared to pLKO tumors. Bars are average of tumors in (C, F) ± SD. P-values are from unpaired t-test. **** < 0.0001