Skip to main content
Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities

Fig. 2

Modulation of CYP19A1 by COX-2. The graphs represent the means ± SD of three independent quantifications by RT-PCR of CYP19A1 mRNA levels in Ist Mes1, Ist Mes2 and MPP89 cells 3 h after adding PGE2 (A) or 35µM rofecoxib (ROF) versus untreated cells (CNTR) (B). Representative western blots analysis of CYP19A1 expression in Ist Mes1, Ist Mes2 and MPP89 cells 24 h after adding PGE2 (C) or rofecoxib (D). Graphs (E, F) represent the mean ± SD of three independent quantifications of protein band intensities normalized to the loading control from a western blot analysis.*, statistically significant correlation between COX-2 and CYP19A1 (paired Student t test P < 0.05)

Back to article page