Fig. 1

Expression of activated forms of different tyrosine kinase receptors (RTKs) in tumor and normal tissue samples from patients with renal cell carcinoma. A. Diagram of cases analyzed indicating the number of paired samples (tumor and healthy tissue from the same patient), as well as the total number of healthy and tumor tissue samples. B. Images from four representative dot blots of renal tumor samples and their normal counterparts from four different patients. C. Phosphorylation level of different RTKs, calculated as the mean pixel intensity of antibody duplicates relative to the reference dots. The red dashed square shows the Mann-Whitney U test comparison for EGFR activation between the normal and tumor tissue. D. pEGFR intensity in paired samples from 20 different renal cell carcinoma patients. E. Pie chart showing the percentage of paired samples where levels of pEGFR were higher, lower or equal in the tumor samples than in the healthy tissue counterpart