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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Altered proTGFα/cleaved TGFα ratios offer new therapeutic strategies in renal carcinoma

Fig. 3

TGFα protein levels in renal cancer patients. A. (Left) Schematic representation of proTGFα structure, indicating domains and the proteolytic cleavage sites that lead to the membrane anchored proTGFα or tail. The antibody used for western blotting detection is showed as well. (Right) Western blot showing the different forms of TGFα detected in a renal cell carcinoma sample. B. Protein levels of different molecular forms of TGFα in normal and tumor kidney tissues from 24 patients. The same antibody was used for both the immunoprecipitation and the western blot. C. Ratio of proTGFα and tail fragment between tumor and normal tissue, calculated as the mean pixel intensity of the upper band (17 KDa) to the lower band (15 KDa) of the above WB scans. p-value was calculated by the Mann-Whitney U test. D. Pie chart showing the percentage of paired samples where levels of TGFα were higher (pink), lower (green) or equal (yellow) in the tumor samples than in the healthy tissue counterpart

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