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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Altered proTGFα/cleaved TGFα ratios offer new therapeutic strategies in renal carcinoma

Fig. 4

Expression of EGFR and TGFα in kidney cancer cell lines. A. Differential expression of EGFR and B. TGFA in different cancer cell lines. RNA-Seq data were obtained from the Cancer Cell Line Encyclopedia. The number of different cell lines for each cancer subtype is indicated in brackets and the data corresponding to the expression of both genes in kidney are highlighted with a red dashed square. C. Phosphorylation level of different RTKs, calculated as the mean pixel intensity of dot duplicates from the antibody array relative to the reference dots (in a.u.). D. Protein levels of phosphorylated and total EGFR, as well as two ligands (TGFα and amphiregullin) in kidney cancer cell lines. E. Level of expression (measured by quantitative PCR) of the seven EGFR ligands in the cell lines. Data are represented as 2^-delta Ct, in arbitrary units (a.u.). U_AE, upper aerodigestive; ESO, esophagus; KID, kidney; U_TR, urinary tract; THY, thyroid; PANC, pancreas; BD, bile duct; L_NSC, lung non-small cell carcinoma; LIV, liver; PROS, prostate; GLI, glioma; STO, stomach; OV, ovary; END, endometrium; CR, colorectal; OST, osteosarcoma; BRE, breast; NEU, neuroblastoma; S_TIS, soft tissue; MEL, melanoma; LSC, lung small cells; HL, Hodgkin lymphoma; E_SAR, Ewing sarcoma; BL, Burkitt lymphoma; DLBCL, diffuse large B-cell lymphoma; T_ALL, T-cell acute lymphoid leukemia; B_ALL, B-cell acute lymphoid leukemia; MM, multiple myeloma; AML, acute myeloid leukemia; CML, chronic myeloid leukemia

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