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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: The CD112R/CD112 axis: a breakthrough in cancer immunotherapy

Fig. 2

CD112R and CD112 expression in health and tumor microenvironment. (A) In normal human peripheral blood cell subsets, CD112R is predominantly expressed in NK cells and CD8+ T cells, but not in CD4+ T cells, DCs, neutrophils, monocytes and B cells. CD112R+CD8+ T cells are mainly detected in effector memory T (CD45RACCR7) cell in phenotype, and rarely in naïve T (CD45RA+CCR7+) cells. (B) In mouse, CD112R are detectable in NK cells and NKT cells, but are barely detectable in CD4+ T cells and CD8+T cells. (C) In the tumor microenvironment, CD112R is expressed abundantly in NK cells, CD4+ T cells and CD8+ T cells. Meanwhile, CD112 was detectable primarily in DCs, tumor-associated macrophages (TAMs) or monocytes, and tumors cells

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