Fig. 6
From: Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy
Synergistic anti-tumor effects of PD-L1 blockage and MET inhibition in an orthotopic mouse model. A Drug treatment protocol for capmatinib and PD-L1 antibody in C57/BL6 mice. At the endpoint, tumors were extracted and assessed via flow cytometry. B-E Sizes of orthotopic KPC xenografts after treatment with capmatinib and/or PD-L1 antibody in C57/BL6 mice. Mouse body weights (B), representative tumor images (C), tumor volumes (D), and tumor weights (E) are shown. F Quantification of CD3 + T cells in CD45 + lymphocytes from purified tumor-infiltrating lymphocytes. G Quantification of the staining of CD8 + T cells in CD45 + lymphocytes from isolated tumor-infiltrating lymphocytes