Skip to main content
Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells

Fig. 9

A Proposed Regulatory Triangle Model for Tumor Progression Involving RSL1D1, p53, and HDM2. In this model, RSL1D1 directly downregulates p53 by recruiting it to HDM2 to form a transient ternary protein complex, thereby enhancing HDM2-mediated p53 ubiquitination and degradation. RSL1D1 also indirectly downregulates p53 by stabilizing HDM2 mRNA to increase the protein level of HDM2. The ensuing low expression of p53 target genes, such as p21 and PUMA, facilitates the proliferation and survival of CRC cells, which is conducive to tumor progression

Back to article page