Fig. 2

The functional domains of human AGR2 and AGR3 proteins and their 3D structure. (A) Primary sequences of human AGR2 and AGR3 and their different domains: Cleavable signal peptide, Pseudo-thioredoxin motif, Dimerization motif, Peptide binding loop, ER Retention signal. The sequences are extracted from the UniProtKB database (www.uniprot.org). The 3D structures of human AGR2 (B) and AGR3 (C) extracted from the RcsbPDB database (www.rcsb.org) and visualized using PyMOL software