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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

Fig. 5

Histological and prognostic comparison of hepatocarcinogenesis between zebrafish and humans. a Tumour incidence rates in pten KO and pten;tp53 cKO fish (n = 100 per group with triplicates). The tumour incidence rates were confirmed by histological examination of dissected pten KO and pten;tp53 cKO fish at different time points. b Quantification of the malignancy of the tumours derived from fish with various mutations at 3 or 6 months of age. c Representative histological images indicating the expression of GS, PCNA, pHH3, and pAkt in tumours derived from humans and zebrafish with different mutations (fabp10WT, pten KO and pten;tp53 cKO fish). Scale bars, 100 μm. d, e PCNA expression was correlative with prognosis in HCC patients (n = 97, d) and pten;tp53 cKO fish (n = 100, e). f Correlation between PCNA expression and malignancy grade in HCC patients (n = 97), pten KO (n = 30), and pten;tp53 cKO fish (n = 28). The data are shown as the mean ± SEM values. *p < 0.05, **p < 0.01, ***p < 0.001

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