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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

Fig. 2

Deficiency of hepatocyte p65 inhibited hepatocellular carcinogenesis and cancer growth in mice. L-p65 wild-type (WT) and L-p65 knockout (KO) mice were treated with a single DEN (15 mg/kg) to induce mouse hepatocellular carcinoma. a MRI images of vehicle- and DEN-induced liver tumours. b Photographs of vehicle- and DEN-induced liver tumours at 9 months. c Representative H&E staining of DEN-induced liver tumours in WT and L-p65-KO mice. d Ki67 staining of a DEN-induced liver tumour. e The growth curve of xenograft tumours of Hep3B cells subjected to vehicle (normal saline) or PDTC (an inhibitor of IκB). Data are expressed as the mean ± SD (n = 5 in each group); *P < 0.05 using Student’s t-test. f Xenograft tumours of Hep3B cells subjected to vehicle (top) or PDTC (bottom) at the end of the experiment. g Xenograft tumour volumes and tumour weights from different treatment groups at the end of the experiment. h Representative H&E, p65 and Ki67 staining of xenograft tumours in the Hep3B vehicle and PTDC groups. Data were expressed as the mean ± SD (n = 5 in each group). P < 0.05 using Student’s t-test

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