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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

Fig. 4

Inhibition of NF-κBp65 phosphorylation depressed hepatocellular proliferation. a Morphological changes that occurred when LO2, HepG2, HepG2.2.15 and Hep3B cells were treated with Bay 11-7082 (an inhibitor of IκB) and observed under bright field microscopy. Bay 11-7082 can inhibit the proliferation of cells. b Colony formation was suppressed in LO2, HepG2, HepG2.2.15 and Hep3B cell lines in the presence of Bay 11-7082. c, d, e Cell growth curves after Bay 11-7082 treatment. f The relative colony formation numbers of Bay 11-7082-treated cells are shown. All values are the means ± SD of three separate experiments and were repeated three times. P < 0.05 using Student’s t-test

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