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Table 1 Association of circRHOBTB3, miR-600, NACC1 expression with the clinicopathological features of 110 PDAC patients

From: FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Characteristics

circRHOBTB3 expression level

miR-600 expression level

NACC1 expression level

High

Low

P-value

High

Low

P-value

High

Low

P-value

Total cases

55

55

 

55

55

 

55

55

 

Gender

 Male

38

37

0.838

39

36

0.539

38

37

0.838

 Female

17

18

 

16

19

 

17

18

 

Age (year)

  < 60

41

32

0.069

32

41

0.069

40

33

0.158

  ≥ 60

14

23

 

23

14

 

15

22

 

Serum CA19–9(U/mL)

 CA19–9 < 39

5

14

0.076

11

8

0.545

6

13

0.209

 39 ≤ CA19–9 < 1000

38

31

 

35

34

 

36

33

 

 CA19–9 ≥ 1000

12

10

 

9

13

 

13

9

 

Location

 Head

36

37

0.84

36

28

0.738

37

37

1

 Body/tail

19

18

 

19

17

 

18

18

 

Diameter (cm)

  ≤ 4

36

48

0.007**

47

37

0.025*

32

51

< 0.0001***

  > 4

19

7

 

8

18

 

23

4

 

Differentiation

 Poor/moderate

36

33

0.554

33

36

0.554

33

35

0.695

 Well

19

22

 

22

19

 

22

20

 

Vascular invasion

 Present

44

33

0.022*

30

43

0.009**

40

35

0.306

 Absent

11

22

 

25

12

 

15

20

 

Nerve invasion

 Present

52

47

0.112

49

49

1

49

50

0.751

 Absent

3

8

 

6

6

 

6

5

 

T stage

 T1/T2

24

36

0.022*

36

24

0.022*

26

33

0.181

 T3/T4

31

19

 

19

31

 

29

22

 

N stage

 N0

21

26

0.335

26

21

0.335

26

21

0.335

 N1/N2

34

29

 

29

34

 

29

34

 

M stage

 M0

54

54

1

54

54

1

55

53

0.154

 M1

1

1

 

1

1

 

0

2

 

Clinical stage

 I-IIa

18

20

0.688

25

13

0.016*

19

19

1

 IIb-IV

37

35

 

30

42

 

36

36

 

Postoperative Recurrence or liver metastasis

 Present

31

31

1

33

31

0.699

33

30

0.563

 Absent

24

24

 

22

24

 

22

25

 
  1. All data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001