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Table 1 Association of circRHOBTB3, miR-600, NACC1 expression with the clinicopathological features of 110 PDAC patients

From: FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Characteristics circRHOBTB3 expression level miR-600 expression level NACC1 expression level
High Low P-value High Low P-value High Low P-value
Total cases 55 55   55 55   55 55  
Gender
 Male 38 37 0.838 39 36 0.539 38 37 0.838
 Female 17 18   16 19   17 18  
Age (year)
  < 60 41 32 0.069 32 41 0.069 40 33 0.158
  ≥ 60 14 23   23 14   15 22  
Serum CA19–9(U/mL)
 CA19–9 < 39 5 14 0.076 11 8 0.545 6 13 0.209
 39 ≤ CA19–9 < 1000 38 31   35 34   36 33  
 CA19–9 ≥ 1000 12 10   9 13   13 9  
Location
 Head 36 37 0.84 36 28 0.738 37 37 1
 Body/tail 19 18   19 17   18 18  
Diameter (cm)
  ≤ 4 36 48 0.007** 47 37 0.025* 32 51 < 0.0001***
  > 4 19 7   8 18   23 4  
Differentiation
 Poor/moderate 36 33 0.554 33 36 0.554 33 35 0.695
 Well 19 22   22 19   22 20  
Vascular invasion
 Present 44 33 0.022* 30 43 0.009** 40 35 0.306
 Absent 11 22   25 12   15 20  
Nerve invasion
 Present 52 47 0.112 49 49 1 49 50 0.751
 Absent 3 8   6 6   6 5  
T stage
 T1/T2 24 36 0.022* 36 24 0.022* 26 33 0.181
 T3/T4 31 19   19 31   29 22  
N stage
 N0 21 26 0.335 26 21 0.335 26 21 0.335
 N1/N2 34 29   29 34   29 34  
M stage
 M0 54 54 1 54 54 1 55 53 0.154
 M1 1 1   1 1   0 2  
Clinical stage
 I-IIa 18 20 0.688 25 13 0.016* 19 19 1
 IIb-IV 37 35   30 42   36 36  
Postoperative Recurrence or liver metastasis
 Present 31 31 1 33 31 0.699 33 30 0.563
 Absent 24 24   22 24   22 25  
  1. All data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001