FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Table 1 Association of circRHOBTB3, miR-600, NACC1 expression with the clinicopathological features of 110 PDAC patients

Characteristics	circRHOBTB3 expression level			miR-600 expression level			NACC1 expression level
Characteristics	High	Low	P-value	High	Low	P-value	High	Low	P-value
Total cases	55	55		55	55		55	55
Gender
Male	38	37	0.838	39	36	0.539	38	37	0.838
Female	17	18		16	19		17	18
Age (year)
< 60	41	32	0.069	32	41	0.069	40	33	0.158
≥ 60	14	23		23	14		15	22
Serum CA19–9(U/mL)
CA19–9 < 39	5	14	0.076	11	8	0.545	6	13	0.209
39 ≤ CA19–9 < 1000	38	31		35	34		36	33
CA19–9 ≥ 1000	12	10		9	13		13	9
Location
Head	36	37	0.84	36	28	0.738	37	37	1
Body/tail	19	18		19	17		18	18
Diameter (cm)
≤ 4	36	48	0.007**	47	37	0.025*	32	51	< 0.0001***
> 4	19	7		8	18		23	4
Differentiation
Poor/moderate	36	33	0.554	33	36	0.554	33	35	0.695
Well	19	22		22	19		22	20
Vascular invasion
Present	44	33	0.022*	30	43	0.009**	40	35	0.306
Absent	11	22		25	12		15	20
Nerve invasion
Present	52	47	0.112	49	49	1	49	50	0.751
Absent	3	8		6	6		6	5
T stage
T1/T2	24	36	0.022*	36	24	0.022*	26	33	0.181
T3/T4	31	19		19	31		29	22
N stage
N0	21	26	0.335	26	21	0.335	26	21	0.335
N1/N2	34	29		29	34		29	34
M stage
M0	54	54	1	54	54	1	55	53	0.154
M1	1	1		1	1		0	2
Clinical stage
I-IIa	18	20	0.688	25	13	0.016*	19	19	1
IIb-IV	37	35		30	42		36	36
Postoperative Recurrence or liver metastasis
Present	31	31	1	33	31	0.699	33	30	0.563
Absent	24	24		22	24		22	25

ISSN: 1756-9966