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Table 2 Univariate and multivariate analysis of prognostic factors in PDAC patients (n = 110)

From: FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Variables Univariate analysis Multivariate analysis
Cases Events Median survival (months) P value HR 95%CI P value
Gender, male/ female 75/ 35 53/ 24 20.0/ 19.2 0.850    
Age, < 60/ ≥60 (year) 37/ 73 21/ 56 27.4/ 18.2 0.027*    0.069
Serum CA199 (U/ml)
  < 39, ≥39 19/ 69 11/ 50 28.4/ 19.3 0.097    
  ≥ 39, ≥1000 69/ 22 50/ 16 19.3/ 14.1 0.550    
  < 39, ≥1000 19/ 22 11/ 16 28.4/ 14.1 0.061    
Location, head/ body or tail 73/ 37 51/ 26 20.0/ 18.5 0.797    
Diameter, ≤4/ > 4 (cm) 84/ 26 53/ 24 25.2/ 9.1 < 0.001***    0.407
Differentiation, poor,moderate/ well 69/ 41 48/ 29 20.0/ 19.2 0.968    
Microscopic vascular invasion,absent/ present 33/ 77 19/ 58 30.3/ 18.2 0.027*    0.109
Microscopic nerve invasion, absent/ present 11/ 99 8/ 69 19.3/ 20.0 0.848    
T stage, T1, 2/ T3, 4 60/ 50 36/ 41 26.8/ 12.9 0.001** 1.728 1.447–3.869 0.025*
N stage, N0/ N1,2 47/ 63 30/ 47 25.3/ 18.2 0.109    
M stage, M0/ M1 108/ 2 75/ 2 19.3/ 22.0 0.816    
Clinical stage, I-IIa/ IIb-IV 38/ 72 19/ 58 34.1/ 17.7 < 0.001*** 2.661 1.513–4.678 0.001**
circRHOBTB3 expression, low/ high 55/ 55 34/ 43 25.4/ 14.2 0.005** 2.700 1.636–4.456 < 0.001***
miR-600 expression, low/ high 55/ 55 51/ 26 26.1/ Undefined < 0.001*** 0.179 0.103–0.309 < 0.001***
NACC1 expression, low/ high 55/ 55 32/ 45 27.6/ 13.9 < 0.001*** 2.366 1.447–3.869 0.001**