FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Table 2 Univariate and multivariate analysis of prognostic factors in PDAC patients (n = 110)

Variables	Univariate analysis				Multivariate analysis
Variables	Cases	Events	Median survival (months)	P value	HR	95%CI	P value
Gender, male/ female	75/ 35	53/ 24	20.0/ 19.2	0.850
Age, < 60/ ≥60 (year)	37/ 73	21/ 56	27.4/ 18.2	0.027*			0.069
Serum CA199 (U/ml)
< 39, ≥39	19/ 69	11/ 50	28.4/ 19.3	0.097
≥ 39, ≥1000	69/ 22	50/ 16	19.3/ 14.1	0.550
< 39, ≥1000	19/ 22	11/ 16	28.4/ 14.1	0.061
Location, head/ body or tail	73/ 37	51/ 26	20.0/ 18.5	0.797
Diameter, ≤4/ > 4 (cm)	84/ 26	53/ 24	25.2/ 9.1	< 0.001***			0.407
Differentiation, poor,moderate/ well	69/ 41	48/ 29	20.0/ 19.2	0.968
Microscopic vascular invasion,absent/ present	33/ 77	19/ 58	30.3/ 18.2	0.027*			0.109
Microscopic nerve invasion, absent/ present	11/ 99	8/ 69	19.3/ 20.0	0.848
T stage, T1, 2/ T3, 4	60/ 50	36/ 41	26.8/ 12.9	0.001**	1.728	1.447–3.869	0.025*
N stage, N0/ N1,2	47/ 63	30/ 47	25.3/ 18.2	0.109
M stage, M0/ M1	108/ 2	75/ 2	19.3/ 22.0	0.816
Clinical stage, I-IIa/ IIb-IV	38/ 72	19/ 58	34.1/ 17.7	< 0.001***	2.661	1.513–4.678	0.001**
circRHOBTB3 expression, low/ high	55/ 55	34/ 43	25.4/ 14.2	0.005**	2.700	1.636–4.456	< 0.001***
miR-600 expression, low/ high	55/ 55	51/ 26	26.1/ Undefined	< 0.001***	0.179	0.103–0.309	< 0.001***
NACC1 expression, low/ high	55/ 55	32/ 45	27.6/ 13.9	< 0.001***	2.366	1.447–3.869	0.001**

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