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Table 2 Expression of select pyroptotic components in cancers and their associated consequence(s)

From: Pyroptosis at the forefront of anticancer immunity

Cancer type Setting Cancer line/ model/tissue Pyroptotic component Relative expression Associated consequence(s) of relative expression Ref
Breast cancer In vivo: human Primary tissue GSDMB Increased ↑ Metastasis & ↓ Patient survival [46]
In vivo: human Primary tissue GSDME Decreased ↑ Metastasis [47]
In vitro: - MDA-MB-231   Decreased* ↑ Invasion [47]
In vivo: human Primary tissue Caspase-1 Decreased N/A [48]
In vitro: - MDA-MB-231   Decreased* ↑ Proliferation & Invasion [48]
In vivo: human Primary tissue NLRP1 Increased ↑ Metastasis [49]
In vivo: mouse MCF-7   Increased ↑ Tumorigenicity & Invasion [49]
Colorectal cancer In vivo: mouse LoVo GSDMC Increased ↑ Tumor growth [50]
In vitro: - DLD-1, LoVo   Increased ↑ Proliferation [50]
In vivo: human Primary tissue GSDME Decreased N/A [51]
In vitro: - HCT116   Decreased* ↑ Cell growth [51]
In vivo: human Primary tissue AIM2 Decreased ↓ Patient survival [52]
In vivo: mouse AOM-DSS Caspase-1 Decreased* ↑ Tumorigenesis [53]
In vivo: human Primary tissue NLRP1 Decreased ↑ Metastasis & ↓ Patient survival [54]
Gastric cancer In vitro: - MKN28 GSDMA Decreased ↑ Cell growth [55]
In vivo: human Primary tissue GSDMB Decreased N/A [35]
In vitro: - MKN28   Increased* No change in cell growth [56]
In vitro: - MKN28 GSDMC Increased* ↓ Cell growth [56]
In vivo: human Primary tissue GSDMD Decreased N/A [57]
In vivo: mouse BGC823   Increased* ↓ Tumor growth [57]
In vivo: human Primary tissue GSDME Decreased N/A [58]
In vivo: mouse AOM   Decreased* No changes reported [59]
Glioma In vivo: human Primary tissue Caspase-1 Increased N/A [60]
In vitro: - U87, T98G   Increased* ↑ Proliferation & Mobility [60]
Hepatocellular carcinoma In vivo: human Primary tissue AIM2 Decreased ↑ Tumor progression [61]
In vitro: - HuH-7   Increased* ↓ Proliferation & Invasion [61]
Lung cancer In vivo: human Primary tissue GSDMD Increased ↑ Tumor size & [27]
In vivo: mouse PC9   Decreased* ↑ Metastasis stage
↓ Tumor growth
[27]
Melanoma In vitro: - 1205Lu NLRP1 Increased* ↑ TMZ resistance [62]
In vivo: human Primary tissue   Decreased N/A [63]
In vivo: mouse 1205Lu   Decreased* ↓ Tumor growth [63]
Prostate cancer In vivo: human Primary tissue Caspase-1 Decreased N/A [64]
  1. * indicates expression was forced or a consequence of experimental treatment during functional studies. The term relative expression is used broadly here and includes mRNA and/or protein level expression depending on the study. AIM2, absent in melanoma 2; AOM, azoxymethane; DSS, dextran sodium sulfate; GSDMA/B/C/D/E, gasdermin A/B/C/D/E; NLRP1, NLR family pyrin domain-containing 1; TMZ, temozolomide