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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: The non-canonical mechanism of ER stress-mediated progression of prostate cancer

Fig. 7

ATF6-mediated ER stress in patients with different rates of alcohol consumption. (A) Tissue sections from PCa patients with a Gleason score 7 were subjected to PLA using a combination of S1P/GCC185 Abs. Representative images from these patients are presented; all images were acquired with the same imaging parameters; bars, 10 μm. (B) Quantification of the PLA signal from samples presented in A. (**P < 0.01, pairwise Wilcoxon with Bonferonni-Hochberg multiple test; N = 14 for each group of patients). (C) The hematoxylin and eosin stain of the cribriform patterns from PCa patients with different alcohol consumption levels but the same Gleason score 7 (4 + 3 or 3 + 4); bars, 50 μm. (D) Quantification of the area of cribriform from samples presented in C (*P < 0.05, Mann-Whitney test). (E) Immunostaining of ATF6 (red) in the representative tissues from samples shown in C. White boxes indicate area magnified below; bars, 10 μm. (F) Quantification of ATF6 intranuclear intensity in cells from E (*P < 0.05, Mann-Whitney test). In B, D, and F, data are presented as medians (min – max)

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