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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Poliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy

Fig. 2

Created with BioRender.com. Receptors DNAM-1 and TIGIT cell extrinsic mechanisms: DNAM-1+ Tregs exert weak suppressive capacity with significantly increased cytokine IL-10 production. TIGIT binding to its ligands expressed on dendritic cells (DCs) inhibits T cell activation by enhancing the production of IL-10 and reducing the production of IL-12 in DCs, which creates an immunosuppressive microenvironment. TIGIT+ Tregs exhibit enhanced suppressive capacity by augmenting Treg suppression and stability with high expression of IL-10, perforin, and TGF-β. The bidirectional arrow represents the interaction between receptors and their ligands. The thickness of the arrow represents affinity between receptors and their common ligand. TIGIT indirectly inhibits T cell activation by directly completing DNAM-1 binding to their common ligand. TIGIT inhibits T cell activation by disrupting CD226 cis-homodimerization in human T cells

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